Reina Sofia hospital has already completed 42 years of life. Since its inauguration, in 1976, it owes much of its prestige to the involvement of its professionals, which has enabled it to conquer many achievements thanks to its organ donation and transplantation program, which has served as an undisputed hallmark of excellence and as a driving force for the rest of units.

The history of the four decades of this hospital is a carousel of emotions and achievements that has never stopped. It is a university hospital since 1985, and the interest in research also has a long history. Today, biomedical research is carried out in collaboration with the Maimónides Institute of Biomedical Research of Córdoba (IMIBIC).

Currently, the Reina Sofía complex is made up of eight buildings, the care activity is organized in 42 clinical management units, and around 5,000 professionals work daily in the hospital to improve the health of the people of Cordoba and Andalusia.

Cordoba was founded by the Romans and due to its strategic importance as the highest navigable point of the Guadalquivir River, it became a port city of great importance, used for shipping Spanish olive oil, wine and wheat back to Ancient Rome. The Romans built the mighty bridge crossing the river, now called "El Puente Romano". But Cordoba's hour of greatest glory was when it became the capital of the Moorish kingdom of El-Andalus, and this was when work began on the Great Mosque, or "Mezquita", which – after several centuries of additions and enlargements – became one of the largest in all of Islam.

When the city was reconquered by the Christians in 1236, the new rulers of the city were so awed by its beauty that they left it standing, building their cathedral in the midst of its rows of arches and columns, and creating the extraordinary church-mosque we see today.